関西医科大学雑誌
Online ISSN : 2185-3851
Print ISSN : 0022-8400
ISSN-L : 0022-8400
高圧電子線大量照射による頭蓋骨同種移植に関する実験的研究
三宅 功
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1972 年 24 巻 3 号 p. 309-328

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Cathode ray irradiation provided by a Van de Graaff generator has been used to sterilize various tissues destined for grafting. An immunological study on the peripheral nerve homotransplantation disclosed a powerful immuno-suppressive effect of the high-voltage electron irradiation.
The purpose of the present report is to prove an availability of the cathode ray irradiation to the homologous skull bone transplantion. The irradiated bone grafts were prepared following the method described by Bassett et al.
Fresh bones, decalcified bones and the irradiated bones we re comparatively studied for their capacities of the immuno-suppressive effects and the new bone formations in a preliminary experiment, where the homologous bone chips were transplanted to the defects of the skulls in rabbits. A superior bone conduction was provided by the irradiated grafts.
New bone formation was recognized along the margins of the grafts 3 months after the homotransplantions of the irradiated canine bones.12 months after operation, bone replacement spread all over the irradiated homografts,25mm in diameter.

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