1974 年 26 巻 4 号 p. 428-449
Incidence of human breast cancer is high in developed countries and low in undeveloped countries with the notable exception of Japan. Among the factors responsible for the incidence of breast cancer, genetic, racial, hormonal and nutritional factors were thought to be important modifiers. Because of the paucity of information dealing with the relationship between mammary carcinogenesis and dietary protein, a further study of this problem seems justified.
In this paper, to clarify the relationship between dietary protein and mammary carcinogenesis, the following experiments were undertaken. Part I of this study is concerned with the effect of arginine imbalanced diets and various proportions of casein diets on genesis and growth of mammary carcinoma in rats induced by 7,12-DMBA. The experimental animals were female Sprague-Dawley rats. The diets used in this experiment were as follows: Group I.50% casein diet Group II.20% casein diet Group III.8% casein diet Group IV.15% casein supplemented with 5% arginine Group V. CMF type of pellet (Oriental Yeast Co. ) These diets were given isocalorically every day. The rats were injected with 3 mg of DMBA at the age of 52 and 55 days. All animals were examined every day during the experimental period, and the onset and evolution of the tumors were recorded. The following results were obtained: 1. The normal body growth rates were not retarded on arginine imbalanced diets, and no ill effects of arginine were shown.