N-methyl-N-nitrosourethane(MNU)の投与によるマウス血管腫瘍の発生

抄録

The dd-strain mice, in which the intraperitoneal injection of 0.15mg of MNU were repeatedly performed, were observed for 28 to 32 weeks. In both sexes, the high frequency of development of vascular tumor was observed in spleen. Moreover, in the female mice, the vascular tumor was demonstrated in uterus or ovary, and, in the male mice, it was demonstrated in seminal vesicle or epididymis. In the mice, in whieh MNU was administerd less than 2 weeks (and total dosage of MNU was below O.6mg)the development of vascular tumor was not observed, but, in the mice, in which MNU was injected more than 4 weeks (and total dosage of MNU was over 1.2 mg), the development of hemangioma or hemangioendothelioma was demonstrated. In the mice, in which MNU was administered more than 12 weeks (and total dosage of MNU was over 3.6mg), the development of hemangioendothelial sarcoma was detected.