副腎皮質ステロイドとACTHの血液・骨髄像に及ぼす影響についての研究

第III編 臨床例についての観察

抄録

The relation between corticosteroid administration and blood picture was investigated in forty-six patients with various diseases other than blood disorders (16 cases of liver diseases (LV),8 cases of nephrotic syndrome (NP),9 cases of bronchial asthma (AS),3 cases of pleurisy (FL), and 10 cases of SLE (SL)).
The results obtained were as follows:
The RCC became slightly increased in LV and PL, but decreased or showed no change in NP, AS, and SL Marked increases in the NC was observed in LV and NP, which were afterwards replaced by increases in the LC. No remarkable changes were observed in the NC of AS and PL. SL showed quite different changes: the NC increased immediately after the beginning of treatment, while the LC increase was delayed though it finally reached a high level in concomitance with the RCC and the NC after treatment for more than eighty days. This finding in SL seemed to be due to the recovery of hematopoietic function caused by improvement of the disease. Younger neutrophils appeared to accompany these neutrophil increases. As seen above, the blood reac tions to corticosteroid administration differed according to the disease; this finding could be attributed to the different pathophysiological states, especially the endocrinological and hematological ones.