各種抗生物質の血管透過性におよぼす影響

第2編HistamineおよびBradykininの皮膚血管透過性増強効果におよぼす各種抗生物質の影響について

抄録

Using Evans blue to observe the influence on capillary permeability produced by antibiotics (CBPC, SBPC, CET, and CEZ administered i. v. at 400 & 9 mg/kg), the diameter changes in the bluing lesions induced on the dorsal skin of rats of histamine, bradykinin, and urokinase were measured at 5 and 30 minutes following antibiotic administration in comparison with i. v. NaC1 administration. The results were as follows:
1) Using Histamine:
a) At 5 minutes, t h e diameter of the bluing lesion was increased by both administrations, the effects of the weaker administration being weaker.
b) At 30 minutes, the diameter of the bluing lesion was increased by both administrations, their effects being the same.
c) The effects of both admini s t rations were stronger at 5 minutes than they were at 30 minutes.
2 ) Using Bradykinin:
a) At 5 minutes, th e diameter of the bluing lesion was increased by both administrations, the effects of the greater dosage being only slightly stronger than that of the lesser dosage.
b) At 30 minutes, the diameter of the bluing lesion produced by the higher bradykinin concentrations were increased by both administrations.
c) At 5 and 30 minutes, the effects o f the antibiotic administrations were about the same, but on lesions induced by low concentrations of bradykinin, the effects were slightly weaker at 5 minutes than they were at 30 minutes.
3) Using Urokinase: No effects of antibiotic administration could be observed.
4) The effects of CBPC, SBPC, CET, and CEZ were almost same.