白血病と肝機能

第1編自血病の時代的変遷および最近の本症各期における肝機能.

抄録

Statistical observations were made on the 102 leukemia cases observed during the past twenty-five years at the First Department of Internal Medicine of Kansai Medical University. The distribution of the cases as to age, sex, and disease type was similar to the statistical observations reported by other Japanese authors on the cases of the same era, except that the present cases showed a higher percentage of monocytic leukemia, and, during the final nine years of the era (1967-1975), a marked increase in myelogenous leukemia.
A pronounced prolongation in survival time was observed among the recent cases. In concomitance with course prolongation, the main direct cause of death changed from bleeding to infection, but more recently, deaths from infection were seen tending to decrease. Hepatic function was checked by laboratory tests (GOT, GPT, alkaline phos phatase, total protein, and A/G ratio of sera) at each of the five clinical stages (KIMURA) of leukemia cases without any circulatory failure, severe infections, or drug intoxications: Abnormal data by these tests were more frequently encountered at the terminal stage as well as at the non-effective stage than at the remission of the disease; thus, the incidence of elevated alkaline phosphatase activity paralleled the severity of the clinical picture in myelogenous leukemia, while no significant abnormalities were found in lymphocytic leukemia. Comparing the results of these tests with the histological findings in the liver in eighteen autopsy cases without any severe circulatory disturbances, severe infections or drug intoxications, no significant correlations could be detected.