関西医科大学雑誌
Online ISSN : 2185-3851
Print ISSN : 0022-8400
ISSN-L : 0022-8400
Neurolept-analgesicsの家兎肺気道ダイナミクスに及ぼす影響
田口 仁士
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ジャーナル フリー

1985 年 37 巻 2 号 p. 166-182

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It has been suggested that fentanyl, a synthesized narcotic analgesic, causes bronchoconstriction and elevates airway resistance. However little work has been done to investigate influences of fentanyl upon the lung airway in detail. The purpose of this study is to examine the changes in such parameters of the airway dynamics as lung compliance, airway resistance, and respiratory power in house rabbits.
The animals underw ent artificial ventilation by means of Servo 900 B ventilator while total lung dynamic compliance (C), airway resistance (R) and respiratory power were calculated on the analogue tracings of pressure, flow, volume and multiplication of pressure by flow, respectively. The calculation of airway resistance was carried out after the method developed by O. P. Norlander who had made it possible to elicit the elastic component of the airway pressure independently from the nonelastic one, and thus attained more accurate value. There was also contained another similar investigation with benzonatate, a new antitussive, in this study.
The results were as follows; Fentanyl did not increse R, but decreased it signific antly either in massive dose (20μg/kg), or in another arbitrary dose (8μg/kg) given after droperidol in a similar fashion to clinical NLA. In the propranolol pretreated animals, fentanyl (8μg/kg) produced significant decrease in R. However in the phentolamine pretreated animals, the same dose of fentanyl caused no change in R. These findings suggest that the decrease in R caused by fen tanyl is due to a blocking action of α-receptors in the airway smooth muscle.
C was decreased in all of the investigated groups of animals which included the one serving as control and having artificial ventilation by ventilator alone without any investigated drug administration. However the decrease in C was smaller in the propranolol pretreated group.
Power was increased at twenty minutes after the administration of fentanyl in a ll of the groups except the propranolol pretreated group. The increase in power was elicited by the concomitant rise in the airway pressure.
High dose of benzonatate (2mg/kg) decreased R, while C was decreased in all of the groups with benzonatate and in the control group as well. It is concluded that benzonatate not only inhibits cough reflex in the alveoli and the small airway but relaxes the bronchial smooth muscle in the large airway.

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