Here reported on the unexpected anti-erythrocyte antibodies found in our transfusion unit of Kansai Medical University Hospital during last ten years from Oct.,1975 to Sept.,1984. The unexpected antibodies could be detected in 2.11% of all materials examined. Among these antibodies, anti-Lea, anti-P1 and anti-E (alone) were detected more frequently than others, occupying 29.0%,19.4% and 8.2% of them respectively, and each one case having anti-K1 or anti-Fyb antibody scarcely detectable in Japanese, was found.
The case with anti-K1 was 64 years old woman who had experi enced three pregnancies and had been suffering from chronic bronchitis concomitant with liver cirrhosis. Thrombocytopenia was found at the time of the blood examination. Her anti-K1 antibody was of IgG type, and was detectable only by means of Coombs' test. Although her red blood cell antigen was kk as to the Kell system, we could not examine that of her husband, because he had already died. As for the cause induced her anti-K1 antibody, her previous pregnancies should be considered, while its autologous occurrence due to chronic bronchitis could not be ruled out.
The case with anti-Fyb was 39 years old man, who had been healthy so far, and had never received any blood transfusion. His red cell antigen was Fy(a+b-) as to Duffy system, his anti-Fyb antibody being of IgG type, too, and could be detected only by means of albumi n-Coombs' or Liss-Coombs' test. In this case, causes which might have induced his antibody could not be presumed.
