関西医科大学雑誌
Online ISSN : 2185-3851
Print ISSN : 0022-8400
ISSN-L : 0022-8400
3, 3', 5'-Triiodothyronine Inhibits Angiotensin II-Induced Calcium Mobilization and Formation of Inositol 1, 4, 5-Trisphosphate in Vascular Smooth Muscle Cells
Hiroya MasakiMitsushige NishikawaMasaya UrakamiMitsuo Inada
著者情報
ジャーナル フリー

1994 年 46 巻 1-2 号 p. 4-9

詳細
抄録

The effect of 3,3',5'-triiodothyronine (rT3) on angiotensin II (AII)-induced calcium mobilization and formation of inositol 1,4,5-trisphosphate (IP3) in vascular smooth muscle cells (VSMC) was studied in this paper. rT3 at concentrations of 10 and 50,μM inhibited All (1μM)-induced increase in cytosolic calcium concentration ([Ca2+]i) and IP3 formation in VSMC dose-dependently.
These results indicate the possibility that rT3 which is regarded as an inactive metabolite of thyroxine (T4) has inhibitory effects on vascular smooth muscle function.

著者関連情報
© The Medical Society of Kansai Medical University
前の記事 次の記事
feedback
Top