Studies on the Reaction Attitude of the Histiocytes of the Rabbits with the Insufficient Adrenalglands.

抄録

We could find primarily in our studies on the inflammatory cell reactions in the animals with the insufficient adrenalglands that an increase in the capillary permeability induced by the inflammatory irritant was suppressed in adrenalectomized mice. Afterwards, we could see that the water quantities in the tissue fluids of our experimental adrenalectomized animals were falling off in a remarkable degree. It is well-known that these changes of the water quantities are attributable mainly to a decrease in the intracellular water quantities, accompanied by a decrease in Na quantities. Then we tried to study the diffussion of the powdered dyes in the tissue fluids of the contrast animals and experimental ones (having the experimental insufficient adrenalglands). We could find that the diffusion of the dyes, spreading over the tissues and mixing in the tissue fluids, was suppressed in a reasonable degree in the experimental animals, which we will mention in another paper. In the experimental animal the inflammatory cell reactions were suppressed and we attribute these to the insufficient communications between the extravascular tissues and the intravascular elements and to the depression of the diffusion in the tissues accompanied by the decrease of the water quantities. In the present paper we state that the animals with insufficient adrenalglands suppressed in a reasonable degree the reactions of the histiocytes against the antigen, and that this might be also one of the important factors which depressed the inflammatory cell reactions.
The rabbits, the adrenalglands of which were made insufficient by means of an experimental operation devised by Aoki, were carefully raised for one week after the operation. After recovery from the operation, they were used as the experimental animals. Into both contrast and the experimental animals we injected simultaneously, subcutaneouslly 2c. c. of diluted India ink suspension of horse serum, and we observed the connective tissues in the other hand, we could find in the experimental animal that the histiocytes became old and round cells, only slightly multiplying in number, and we could find nowhere such parts as were paved compactly with the histiocytes with their protoplasms full of degenerated fatty vaauoles. nor could we find the clasmatoid alterations and an increase in their number in the peripheral zone. We can not decide immediately that these reactions are due to the direct action of the hormons of the adrenalglands to the histiocytes. We can speculate reasonably from the above-mentioned results, however, that these marked depressed histiocyte reactions may be one of the important factor which depressed the inflammatory cell reactions in the animals with insufficient adrenalglandij (depression of Arthus' phenomenon being one of them).