脂質栄養学
Online ISSN : 1883-2237
Print ISSN : 1343-4594
ISSN-L : 1343-4594
総説
統合失調症の発達障害仮説と必須脂肪酸の関連についての考察
吉川 武男渡辺 明子前川 素子
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2009 年 18 巻 1 号 p. 81-91

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Deficits in prepulse inhibition (PPI) are a biological marker for schizophrenia. To unravel the mechanisms that control PPI, we performed quantitative trait loci (QTL) analysis, on 1010 F2 mice derived by crossing C57BL/6 (B6) animals that show high PPI with C3H/He (C3) animals that show low PPI. We detected 6 major loci for PPI. A promising candidate on the chromosome 10-QTL was Fabp7 (fatty acid binding protein 7, brain), a gene with functional links to the NMDA receptor and expression in neural stem/progenitor cells in developmental stage. Fabp7-deficient mice indeed showed decreased PPI. A quantitative complementation test supported Fabp7 as a potential PPI-QTL gene. Disruption of Fabp7 attenuated neurogenesis in vivo. Human Fabp7 showed genetic association with schizophrenia. FABP7 is known to have high affinity for polyunsaturated fatty acids, in particular docosahexaenoic acid. These results suggest that FABP7 plays a novel and crucial role, linking the NMDA, neurodevelopmental and nutritional issues of schizophrenia pathology.

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© 2009 日本脂質栄養学会
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