Lipid nutrition is considered to be very important for the growth and development of children, especially low birth weight (LBW) infants. To improve mental development in LBW infants sphingomyelin is very important as well as docosahexaenoic acid. Brain volume measured by MRI is well correlated with head circumference and its gray matter volume has a relationship with triglyceride levels in umbilical blood. Body weight gain in infants is correlated to obesity and abnormal lipid metabolism in adolescent period. We should always consider effects of lipid nutrition on growth and development in children.