機能性脂質のメタボリックシンドローム予防作用

抄録

The metabolic syndrome is a condition characterized by an array of factors including abdominal obesity, dyslipidemia, hypertension and impaired glucose metabolism. Since individuals with metabolic syndrome have a higher risk of morbidity and mortality of cardiovascular disease (CVD), compared with those without metabolic syndromes. Recently our studies provide evidence that dietary factors may improve metabolic syndrome. The current review will discuss the physiological functions and molecular actions of dietary bioactive lipids such as n-3 high unsaturated fatty acids (n-3HUFAs), phospholipids and conjugated fatty acids. The role of bioactive lipids on the prevention of metabolic syndrome and associated metabolic impairments, such as non-alcoholic fatty liver disease (NAFLD) and inflammation were also discussed. Dietary bioactive lipids suppress an accumulation of lipids in the liver, muscle and abdominal adipose tissues through the alteration of transcriptional factors involved in lipid and glucose metabolism and alleviate hypertension and insulin resistance via adiponectin induction.