. Pollinosis by Japanese Cedar in spring has become national phenomenon. Steroid treatment in atopic dermatitis and bronchial asthma is essential, but causes side effects when used improperly. Sophisticated research in allergy will going to develop a new therapy using drugs such as humanized anti-IL5. anti-IgE or DNA-based immunotherapy. Clinical Trials of anti-IL5 remain controversial but the trials using anti-IgE or DNA-based immunotherapy are promising. Our projects involve the traditional and affordable resources such as simple preventive tips and Japanese green tea, and are going to extend clinical trials after preliminary experiments. Comparative reviews of allergy control between Japan and Western countries are introduced from the aspects of culture, food, climate and history.