N-3 polyunsaturated fatty acids and green tea extracts are effective for the prevention of life style related disease. Japanese people have consumed the large amounts of fish and green tea. We have clarified the properties of sardine, catfish, and sea snake lipids. The lipid content of sardines was high from July to September, and the characteristics of the fatty acids isolated from sardines in those period were similar to those from plankton in the same season. Japanese catfish and sea snake lipids showed lower n-3 polyunsaturated fatty acid percentages comparing with general fish oil. However, intake of Japanese catfish lipids decreased the liver total cholesterol as well as the sardine lipid intake. Furthermore the sea snake lipids have stronger lowering-effects on plasma lipids and glucose concentrations than a fish oil mixture containing the same percentage of 22:6n-3. The stimulations intake of fish oil and green tea components were effective for the lowering plasma lipid. Japanese model fat diet lowered the plasma glucose, and green tea extraction intake effectively promotes the influence. The stimulations intake of DHA and catechin showed improved-effects on the brain function. The stimulations intake of fish and green tea are may be effective for the human health.