特定保健用食品としてのリン脂質結合大豆ペプチド

抄録

CSPHP is a newly developed soy peptide that significantly decreases serum concentrations of total cholesterol and LDL cholesterol. It was made by fortifying soy's widely known serum-cholesterol reducing property by binding enzymatically-decomposed lecithin to hydrolyzed isolated soy protein in the ratio of 80:20 (wt/wt). The two components are considered to be bonded hydrophobically. CSPHP is useful for both normalizing the high cholesterol level of hypercholesterolemia patients and also maintaining serum cholesterol level for healthy humans taking high cholesterol meals. By taking 3 or more grams of CSPHP/day for 3 months consecutively, CSPHP reduced both their total cholesterol and LDL-cholesterol level of the hypercholesterolemia patients. Both cholesterol showed a decrease already at 1 month period by 10.4% and 17.1% (vs. initial, ), respectively. The maximum reduction of the two was 15.0% and 27.7% (p<0.05), respectively, which was seen at the end of the 3 month period. Oral CSPHP of 3g also suppressed the serum total and LDL-cholesterol surge significantly when given to healthy humans receiving high cholesterol diet (2 egg yolks/day). Additionally, by taking 3grams of CSPHP/day in drink form for normocholesterolaemic and mildly hypercholesterolaemic subjects, CSPHP also reduced both their total cholesterol and LDL-cholesterol levels.