The Journal of Medical Investigation
Online ISSN : 1349-6867
Print ISSN : 1343-1420
ISSN-L : 1343-1420
Case reports
A case of sarcoidosis accompanying squamous cell carcinoma in the mandibular gingiva
Masaki HanibuchiYuka MatsumoriYasuhiko NishiokaSaburo Sone
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2005 Volume 52 Issue 1,2 Pages 118-121


A 51-year-old man with a history of gingival cancer two years previously was referred to our hospital for further examination of chest abnormal shadow. Bilateral hilar and mediastinal lymphadenopathy, diffuse small nodular opacities and pleural nodules were observed in chest high resolution CT. Serum angiotensin converting enzyme and lysozyme were elevated. Transbronchial lung biopsy specimens demonstrated non-caseous granuloma. CD4-positive lymphocytes were increased in broncho-alveolar lavage (CD4/CD8 ratio 5.47).The patient was diagnosed as having sarcoidosis. Radiological findings were improved and serum angiotensin converting enzyme level was decreased to within the normal range by corticosteroid therapy (prednisolone 30mg/day). This is the first report of sarcoidosis accompanying the gingival cancer. J. Med. Invest. 52: 118-121, February, 2005

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© 2005 by The University of Tokushima Faculty of Medicine
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