The Journal of Medical Investigation
Online ISSN : 1349-6867
Print ISSN : 1343-1420
ISSN-L : 1343-1420
Regional changes of fractional anisotropy with normal aging using Statistical Parametric Mapping (SPM)
Kaori FurutaniMasafumi HaradaMasako MinatoNaomi MoritaHiromu Nishitani
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2005 Volume 52 Issue 3,4 Pages 186-190


Objective: There has been reports on the usefulness of diffusion tensor imaging (DTI) about age-or disease-related degradation. DTI is generally evaluated by the region of interest (ROI) methodology. In this study, we applied a statistical way using Statistical Parametric Mapping (SPM) to assess normal aging by DTI and compared results of these two methods.
Methods: Ten young and ten senior normal volunteers were examined. On SPM, tensor images were changed into normalized tensor images. They were compared between the two groups by t-test.
Results: In the senior group, fractional anisotropy (FA) values were higher on the basal ganglia, cingulated gyrus and other cortical gray matter, lower in the corona radiata, internal capsule, centrum semiovale and corpus callosum by using SPM. In the ROI method, the results were almost compatible except in the brain periphery.
Conclusions: Aging changes on water diffusion anisotropy was clearly shown by SPM method which would be useful to evaluate change of water diffusion anisotropy without operator bias even in clinical setting instead of ROI measurement. J. Med. Invest. 52: 186-190, August, 2005

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© 2005 by The University of Tokushima Faculty of Medicine
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