The Journal of Medical Investigation
Online ISSN : 1349-6867
Print ISSN : 1343-1420
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No relationship exists between PBP 2a amounts expressed in different MRSA strains obtained clinically and their β-lactam MIC values
Md. Anowar Khasru ParvezHirofumi ShibataTatsuro NakanoShingo NiimiNobuo FujiiNaokatu ArakakiTomihiko Higuti
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2008 Volume 55 Issue 3,4 Pages 246-253

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Abstract

After establishing a linear relationship between the amount of penicillin-binding protein (PBP) 2a and membrane proteins of methicillin-resistant Staphylococcus aureus (MRSA) COL by dot-blot analysis using an antibody against PBP 2a, we determined the PBP 2a quantities in membrane fractions prepared from 14 different MRSA cells. Methicillin-sensitive S. aureus ATCC 6538P was used as a quality control strain. The amounts of PBP 2a diverged among the strains, and no relationship to β-lactam MIC values were observed in the corresponding strains. J. Med. Invest. 55: 246-253, August, 2008

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© 2008 by The University of Tokushima Faculty of Medicine
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