Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

Kiyoshi Teshigawara; Toshio Hosaka; Miwa Yamaguchi; Eri Terada; Yuka kisyuku; Keiko Fukunaga; Yohko Hirata; Bayasgalan Jambaldorj; Nagakatsu Harada; Tohru Sakai; Yutaka Nakaya

doi:10.2152/jmi.57.224

Originals

Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

Kiyoshi Teshigawara, Toshio Hosaka, Miwa Yamaguchi, Eri Terada, Yuka kisyuku, Keiko Fukunaga, Yohko Hirata, Bayasgalan Jambaldorj, Nagakatsu Harada, Tohru Sakai, Yutaka Nakaya

Author information

Kiyoshi Teshigawara
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Division of Biofunctional Evaluation Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama
Toshio Hosaka
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Miwa Yamaguchi
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Eri Terada
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Yuka kisyuku
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Keiko Fukunaga
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Yohko Hirata
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Bayasgalan Jambaldorj
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Nagakatsu Harada
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Tohru Sakai
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Yutaka Nakaya
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School

Keywords: HBA, hyperlipidemia, TNFα, MCP1

JOURNAL FREE ACCESS

2010 Volume 57 Issue 3,4 Pages 224-231

DOI https://doi.org/10.2152/jmi.57.224

Details

Abstract

Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus. J. Med. Invest. 57: 224-231, August, 2010

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