Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice

Tohru Sakai; Emi Shuto; Tomoyo Taki; Honami Imamura; Miku Kioka; Akiko Nakamoto; Seiji Mizoguchi; Shouko Amano; Yukari Kawano; Mariko Nakamoto; Rie Tsutumi; Toshio Hosaka

doi:10.2152/jmi.59.95

Originals

Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice

Tohru Sakai, Emi Shuto, Tomoyo Taki, Honami Imamura, Miku Kioka, Akiko Nakamoto, Seiji Mizoguchi, Shouko Amano, Yukari Kawano, Mariko Nakamoto, Rie Tsutumi, Toshio Hosaka

Author information

Tohru Sakai
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Emi Shuto
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Tomoyo Taki
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Honami Imamura
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Miku Kioka
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Akiko Nakamoto
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Seiji Mizoguchi
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Shouko Amano
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Yukari Kawano
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Mariko Nakamoto
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Rie Tsutumi
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Toshio Hosaka
Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School

Keywords: cathepsin E, dendritic cells, MHC class II, NC/Nga mice

JOURNAL FREE ACCESS

2012 Volume 59 Issue 1,2 Pages 95-101

DOI https://doi.org/10.2152/jmi.59.95

Details

Abstract

NC/Nga (NC) mice are an animal model for human atopic dermatitis. We found that induction of antigen (Ag)-specific T cell response is diminished in ovalbumin (OVA)-immunized NC mice. Ability of Ag presentation in NC mouse dendritic cells (DCs) was significantly weaker than that in BALB/c and DBA/2 mouse DCs. Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs. These results indicate that low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice. J. Med. Invest. 59: 95-101, February, 2012

Corresponding author

Register with J-STAGE for free!