New therapeutic approach for hepatocellular carcinoma located periphery of the liver; segmental wedge-shaped necrosis induced by radiofrequency ablation combined with transcatheter arterial embolization

Abstract

We previously reported that radiofrequency (RF) ablation combined with transcatheter arterial embolization (TAE) using iodized oil and gelatin sponge created wedge-shaped necrotic area starting from the ablation zone to the periphery of the liver in animal model. In this study, we evaluated the extended effects of the combination therapy to 17 patients with hepatocellular carcinoma (HCC) located periphery of the liver. Immediately after segmental TAE, RF expandable electrode was inserted to proximal portion of HCC. In 16 of 17 patients, wedge-shaped segmental necrotic area including HCC was confirmed by CT, and no local tumor recurrences were observed during 24-48 months of follow-up periods. Three adverse events (pleural effusion) were related to the treatment. We conclude that this combination therapy makes it possible to induce the wedge-shaped segmental necrosis including HCC.