Journal of Microwave Surgery
Online ISSN : 1882-210X
Print ISSN : 0917-7728
ISSN-L : 0917-7728
Primary Hepatic Carcinoma
Analysis of treatment outcome for lens culinaris agglutinin-reactive alpha-fetoprotein-positive hepatocellular carcinoma in relation to post-treatment disappearance of protein
Yasuko KawasakiKiyohide KiokaTakashi NakaiYumi IshidaHirotsugu MaruyamaShinsuke HiramatsuAroka MoriTakehisa SuekaneTomoaki YamasakiKoji SanoMasatsugu ShibaHiroko NebikiHiroyuki SatoAkishige KanazawaSadatoshi ShimizuTadashi Tsukamoto
Author information
JOURNAL FREE ACCESS

2011 Volume 29 Pages 109-113

Details
Abstract

Purpose: This study was designed to evaluate the influence of the rating “Lens culinaris agglutinin-reactive alphafetoprotein (AFP-L3) positive” on the outcome of treatment.
Materials and methods: The study involved 232 patients with hepatocellular carcinoma rated as having liver damage class AB hepatopathy, a single tumor, tumor diameter 2 cm or smaller, no vascular invasion, and no extrahepatic lesion for whom AFP-L3 (“L3”) was measured at our hospital between 1994 and 2008. In these patients, the outcome of treatment was analyzed in relation to presence/absence (positive/negative) of L3 before treatment and post-treatment disappearance or persistence of L3 in pre-treatment L3-positive cases.
Results: The cumulative survival rate was significantly lower for L3-positive cases than for L3-negative cases (p = 0.008). Neither the cumulative survival rate in L3-positive cases nor the post-treatment L3 disappearance rate in L3-positive cases before treatment differed significantly depending on the method of treatment (p = 0.7501, p = 0.3286). The cumulative survival rate was significantly higher for cases becoming L3 negative after treatment than for those failing to become L3-negative after treatment (p = 0.035).
Conclusion: The prognosis was poorer in L3-positive cases than in L3-negative cases.
Among L3-positive cases before treatment, the prognosis was poorer in cases failing to become L3-negative after treatment than in those becoming L3-negative after treatment.

Content from these authors
© 2011 Study Group of Microwave Surgery
Previous article Next article
feedback
Top