Juntendo Medical Journal
Online ISSN : 2188-2126
Print ISSN : 2187-9737
ISSN-L : 2187-9737
Original Articles
Propensity Score Analysis in the Comparison of Long-Term Outcomes for Locally Advanced Colon Cancer Between Laparoscopic Colectomy and Open Colectomy
KIICHI SUGIMOTOKAZUHIRO SAKAMOTORYOSUKE ICHIKAWAKAZUMASA KUREKUMPEI HONJOHISASHI RORINA TAKAHASHISHINGO KAWANOKOICHIRO NIWASHUN ISHIYAMAHIROHIKO KAMIYAMAHIROMITSU KOMIYAMAMAKOTO TAKAHASHIYUTAKA KOJIMAMICHITOSHI GOTOATSUSHI OKUZAWAYOSHIRO ISHIBIKIYUICHI TOMIKI
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2017 Volume 63 Issue 4 Pages 264-272

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Abstract

Objective: It is difficult to conduct a randomised control trial in a single institution because of the small number of cases. The current study was conducted to investigate if there is any difference in long-term outcome between laparoscopic surgery (LAC) and open surgery (OC) using propensity-score matching analysis based on prognostic factors.

Materials: Two hundred and sixteen patients with locally-advanced colon cancer who underwent surgery with curative intent at our department between 2002 and 2010 were enrolled in the current study.

Methods: Propensity score matching analysis and Inverse Probability Weighting (IPW) estimator were used to adjust for differences in the clinicopathological severity between LAC and OC.

Results: Before propensity score matching analysis recurrence-free survival in LAC was statistically better than that in OC (Hazard ratio= 0.59, 95% CI 0.35-0.98, p=0.04), and no statistically significant difference was recognized for cancer-specific survival (Hazard ratio=0.63, 95% CI 0.27-1.37, p=0.25). After propensity score matching analysis there were no statistically significant differences for recurrence-free (Hazard ratio=0.91, 95% CI 0.41-2.01, p=0.81) or cancer-specific survival (Hazard ratio=1.38, 95% CI 0.41-4.82, p=0.59). In addition, the IPW estimator revealed that the difference for recurrence-free survival was not significant between the two groups.

Conclusion: The one-to-one pair propensity score matching successfully balanced the clinicopathological factors between LAC and OC. The propensity score matching analysis demonstrated no significant difference between LAC and OC.

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© 2017 The Juntendo Medical Society. This is an open access article distributed under the terms of Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original source is properly credited.
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