Abstract
Uncompacted 8-cell mouse embryos cultured in a Whittingham medium containing anti-Lewis X (Lex) antibody underwent compaction, and developed into 16-cell embryos, though their blastomeres were all round and tended to be separated from each other. In such embryos no junctional complexes were seen of any type. These findings seem to suggest that Lex epitope must play an important role in cell-to-cell recognitionin transformed embryos and in the subsequent formation of junctional complexes.
