An oral glucose tolerance test (O-GTT) was conducted in 96 non-obese healthy children (7∼11 years old) and adolescents (12∼16 years old) to obtain the index of insulin resistance from the insulin (IRI) and C-peptide (CPR) values of fasting, 2-hour postload conditions and the Σ values, and the homeostasis model assessment ratio (HOMA-R) by assuming the value of the mean+2SD to be the upper limit of the normal value for each clinical variable. The results show that the adolescents, whose insulin resistance is thought to increase, showed higher IRI and CPR values of the 2-hour postload condition and Σ values compared to those of the children, but there were no differences between the 2 age groups in the values of the fasting condition, as well as in the HOMA-R values which were calculated from the fasting values. These findings indicate that there is a limitation in using fasting values to judge insulin resistance. Instead, using the 2-hour postload values and/or the Σ values is more appropriate.
2004 by the Medical Association of Nippon Medical School