Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice

Yuya Ise; Tomohisa Mori; Shirou Katayama; Tsutomu Suzuki; Tzu-Chueh Wang

doi:10.1272/jnms.81.53

Short Communication

Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice

Yuya Ise, Tomohisa Mori, Shirou Katayama, Tsutomu Suzuki, Tzu-Chueh Wang

著者情報

キーワード: conditioned place preference paradigm, nicotine, mecamylamine, genetic difference, mice

ジャーナルフリー

2014 年 81 巻 1 号 p. 53-56

DOI https://doi.org/10.1272/jnms.81.53

詳細

抄録

This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background.

責任著者(Corresponding author)

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