日本医科大学雑誌
Online ISSN : 1884-0108
Print ISSN : 0048-0444
ISSN-L : 0048-0444
急性ウイルス性肝炎の研究ことにS-GPT, S-GOTの半減期について
矢野 侃
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ジャーナル フリー

1979 年 46 巻 4 号 p. 271-285

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The changes of S-GPT S-GOT, etc. were studied in 48 patients of acute viral hepatitis (AVH), in whom corticosteroid (CS group) was used in 10, and 8 patients in various states of acute circulatory disturbances (ACD group). In acute viral hepatitis not receiving CS (AVH group), GPT and GOT decreased rectilinearly or almost rectilinearly when plotted on a semilogarithmic graph, and the half-lives were calculated as 3.65+0.89 and 2.81+1.27 days, respectively. The half-lives in ACD and CS were significantly shorter than that in AVH. The latter fact verifies the effectiveness of CS on hepatitis, indicating that the comparison of the half-lives is useful for evaluation of the effectiveness of the treatment. A half-lives of GOT was significant correlation between half-lives of the transaminases and the liver function tests examined on admission, except the negative correlation between the half-life and the initial value of GOT. The number of days required for decrease of GPT and GOT to 100 unit were estimated using the half-lives. The obtained values were in good accordance with the actual ones. The number of days estimated for normalization of GPT and GOT (35 and 40 units, respectively) calculated in a similar manner were shorter than the actual ones, but a good coincidence was, obtained by adding 5 days to the calculated values. In most cases showing discrepancies between the predicted and actual days required for normalization, the reason of discordance was found. In cases of AVH admitted before 1970, the predicted days for normalization coincided with the actual ones almost similarly to the present series, indicating the practical usefulness of the prediction using half-life. There was no difference in the half-life between GOTm and GOT, but in some cases GOTm was observed to be more useful for prediction of the course of the disease. The slopes from the initial value of GPT to 100 and 35 units were 46.. and 36.. respectively, in average in the cases, in which the predicted and actual days were not differed by more than 5. Construction using these slopes makes also the prediction of the number of days required for normalization. The days thus obtained were not so much differed from those calculated from half-life in the present series of AVH, and rather better in the old cases.

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