日本神経回路学会誌
Online ISSN : 1883-0455
Print ISSN : 1340-766X
ISSN-L : 1340-766X
研究論文
新皮質ニューロンEPSPの確率的減衰挙動
—Markram-Tsodyks実験の解析—
小山 英之藤江 徳雄宮崎 孝昭大島 裕子
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2000 年 7 巻 4 号 p. 115-120

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Stochastic depression behavior of EPSPs which has been investigated experimentally by Markram and Tsodyks is analyzed using a probabilistic postsynapse model involving a 2-state receptor type and the Morris-Lecar equations. The analysis explains the depression and stationary properties of EPSPs on the basis of saturation and recovery characteristics of the receptor mechanisms. Furthermore, the “after pairing effect” is caused by changes in the receptor sensitivity, according to the present model. The model predictions with various action potential frequencies are in good agreement with the experimental results.

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© 2000 日本神経回路学会
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