SOME BIOLOGICAL PROPERTIES OF THIAMINIC ACID ANALOGUES

Abstract

Thiaminic acid (TnA) and its O-benzoyl derivative (BTnA) had no thiamine activity on love-birds. Oral administration of large dose, daily 600μg thiamine-equivalents, with or without thiamine (3μg daily), resulted in no significant difference in body weight and prolongation of life between the control and the given groups. This finding suggests that the compounds have no antithiamine activity in love-birds when given orally.
The toxicity was found to be very low among the compounds related to thiamine. The LD₅₀ of BTnA for mice by intravenous injection (pH 7.0, aqueous solution) was 1.87g/kg and that of TnA (pH 7.0, aqueous solution) over 4g/kg. No toxic effect was observed after either oral or intraperitoneal administration.