抄録
1. The amount of toxopyrimidine needed for the occurrence of convulsion, followed by death of the dogs after injection into cisterna magna was 6.67mg/kg.
2. Both γ-aminobutyric and γ-amino-β-hydroxybutyric acids have no significant preventive effect on the convulsion induced by toxopyrimidine injection.
3. The amount of isonicotinic hydrazide needed for the occurrence of convulsion followed by death of dogs by intracisternal injection was 6.5mg/kg.
4. Both γ-aminobutyric and γ-amino-β-hydroxybutyric acids have no preventive effect on the convulsion induced by isonicotinic hydrazide. However, there seems to be some differences in the survival rate between the groups injected and the control.
5. Pyridoxine has a preventive effect against the convulsion of dogs induced by an intracisternal injection of toxopyrimidine or isonicotinic hydrazide, whereas γ-amino-butyric and γ-amino-β-hydroxybutyric acids have little, if any, convulsion-preventing action as compared to pyridoxine. They can therefore hardly be said to be central convulsion-preventive substances.
