EFFECT OF RIBOFLAVIN AND RIBOFLAVIN 2', 3', 4', 5'-TETRABUTYRATE ON RAT LIVER MICROSOMAL LIPID PEROXIDATION

Abstract

Effect of riboflavin and riboflavin 2', 3', 4', 5'-tetrabutyrate on microsomal lipid peroxidation in vitro was studied. Riboflavin-tetrabutyrate decreased the lipid peroxide formation measured by thiobarbituric acid reaction and oxygen uptake, and prevented enzyme inactivation at the same time. Riboflavin showed a similar effect, but the effect was less than that of riboflavin-tetrabutyrate. The antioxidative and enzymeprotective effects of flavins were discussed in connection with lipid metabolism in vivo.