Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
ROLE OF ASCORBIC ACID ON TYROSINE HYDROXYLASE ACTIVITY IN THE ADRENAL GLAND OF GUINEA PIG
Yoko NAKASHIMAHiroo SANADARyokuero SUZUEShoji KAWADA
Author information
JOURNALS FREE ACCESS

1976 Volume 22 Issue 5 Pages 355-363

Details
Abstract

The decrease of tyrosine hydroxylase activity in adrenal homogenate in scurvy was recovered after the administration of ascorbic acid. The causes of the increase in the enzyme activity after the administration of ascorbic acid have been studied.
1. No significant elevation in the enzyme activity was observed after the administration of reserpine to the scorbutic guinea pig. 2. A dose of metal chelating agent, α, α'-dipyridyl, prevented the ascorbic acid-induced or reserpine-induced increase in enzyme activity in the scorbutic and the non-scorbutic guinea pigs, respectively. 3. Tyrosine hydroxylase activity was partially recovered by the administration of FeSO4 to the scorbutic guinea pig.
From these results, it became clear that the induction of tyrosine hydroxylase which was not observed in scurvy was due to the deficiency of Fe2+. These results suggested that ascorbic acid affected the induction of this enzyme via Fe2+.

Information related to the author
© the Center for Academic Publications Japan
Previous article Next article
feedback
Top