Anti-Oxidative Effects of Vitamin B₂-Butyrate on the Cardiac Mitochondrial Disorders Induced by Adriamycin

Abstract

The combined use of CoQ₁₀ with adriamycin has beenrecommended for reduction, of the cardiotoxicity that occurs during cancer chemotherapy. Vitamin B₂-butyrate was also investigated in order to determine anti-oxidative effects on adriamycin cardiotoxicity. This vitamin analysis prevented enhanced lipid peroxidation and rectified the respiratory disorders of heart mitochondria induced by adriamycin, however, the deficiency of the CoQ₁₀-pool was not rectified. The combined approach of using CoQ₁₀ for rectifying the deficiency of this component and of using B₂-butyrate for reducing lipid peroxidation was indicated for adriamycin cancer chemotherapy.