1983 Volume 29 Issue 6 Pages 637-642
Effects of long-term administration of riboflavin, sodium butyrate or riboflavin 2', 3', 4', 5'-tetrabutyrate (RTB) on the activities of renal and hepatic enzymes that catalyze the β-oxidation of fatty acid were determined in the rat. Feeding of riboflavin or sodium butyrate for 5 weeks had no effect on all the enzymes examined. By contrast, feeding of RTB resulted in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase [EC 188.8.131.52] by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase [EC 184.108.40.206] and acyl-CoA dehydrogenase [EC 220.127.116.11] remained unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged RTB administration results in an increased β-oxidation of fatty acid in the liver, which may explain the reported reduction in the concentration of tryglyceride in plasma during RTB treatment.