Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Effect of Chronic Administration of Riboflavin 2', 3', 4', 5'-Tetrabutyrate on the Hepatic Enzymes of Fatty Acid Oxidation in the Rat
Etsuo OKUNOMasayuki NAKAMURAYohsuke MINATOGAWARyo KIDOKatsuyuki BABA
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1983 Volume 29 Issue 6 Pages 637-642

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Abstract

Effects of long-term administration of riboflavin, sodium butyrate or riboflavin 2', 3', 4', 5'-tetrabutyrate (RTB) on the activities of renal and hepatic enzymes that catalyze the β-oxidation of fatty acid were determined in the rat. Feeding of riboflavin or sodium butyrate for 5 weeks had no effect on all the enzymes examined. By contrast, feeding of RTB resulted in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase [EC 2.3.1.16] by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase [EC 6.2.1.3] and acyl-CoA dehydrogenase [EC 1.3.99.3] remained unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged RTB administration results in an increased β-oxidation of fatty acid in the liver, which may explain the reported reduction in the concentration of tryglyceride in plasma during RTB treatment.

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