Depression of Phagocytic Activity of Human Polymorphonuclear Leukocytes by Methyl Linoleate Hydroperoxides

Abstract

Methyl linoleate hydroperoxides (MLHPO), a model for lipid hydroperoxides, decreased fungicidal activity of human polymor-phonuclear leukocytes (PMN) for fungi of Candida albicans. When PMN was cultured with MLHPO, phagocytosis to fungi was depressed. Degree of the depression was dependent on the concentration of MLHPO and the treatment time with MLHPO. These findings indicate that phagocytic activity of human PMN can be depressed by lipid hydroperoxides.