Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Metabolism of Orally Administered Ergosterol and 7-Dehydrocholesterol in Rats and Lack of Evidence for Their Vitamin D Biological Activity
Naoko TSUGAWAToshio OKANOAtsuko TAKEUCHIMayumi KAYAMATadashi KOBAYASHI
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1992 Volume 38 Issue 1 Pages 15-25

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Abstract

Metabolism of orally administered ergosterol (Erg) and 7-dehydrocholesterol (7-DHC) in rats and their vitamin D biological activity were investigated. Most of orally administered Erg and 7-DHC were excreted in feces and the remaining sterols were absorbed through intestine. The absorbed sterols were not transported in skin as the intact forms but metabolized into brassicasterol and cholesterol, respectively, within 25h. Neither increment of intestinal calcium absorption nor plasma calcium concentrations were observed by oral administration of Erg and 7-DHC to vitamin D-deficient rats. Therefore, we have concluded that orally administered Erg and 7-DHC have no vitamin D biological activity.

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