Effect of Methyl Linoleate Hydroperoxides on Murine Natural Killer Cell-Mediated Cytotoxicity

Abstract

Methyl linoleate hydroperoxides (MLHPO), a model for lipid hydroperoxides, suppressed murine natural killer (NK) cell-mediated cytotoxicity to YAC-1 cells. When NK cells were cultured with MLHPO, the conjugation of NK cells and YAC-1 cells was not affected, but most of the conjugated NK cells could not lyse YAC-1 cells. These findings suggest that NK cell-mediated cytotoxicity can be suppressed by lipid hydroperoxides.