1996 Volume 42 Issue 6 Pages 589-593
Hepatic cystathionine β-synthase activity was increased in rats fed a high-protein diet for three or five days as compared to rats given laboratory chow (day 0). In the low-protein diet group, the enzyme activity decreased after both feeding periods. Similar changes in the cystathionine β-synthase mRNA levels were observed in the rats fed these diets. The changes in cystathionine β-synthase activity caused by alteration of the dietary protein content were mainly due to changes in the mRNA levels.