Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Dietary Vitamin B6 Suppresses Colon Tumorigenesis, 8-Hydroxyguanosine, 4-Hydroxynonenal, and Inducible Nitric Oxide Synthase Protein in Azoxymethane-Treated Mice
Shun-ichiro KOMATSUHiromitsu WATANABETatsuzo OKAHaruhito TSUGENorihisa KATO
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2002 Volume 48 Issue 1 Pages 65-68

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Abstract

Recently we reported that the supplementation of vitamin B6 to low vitamin B6 diet caused suppression in colon tumorigenesis and cell proliferation of azoxymethanetreated mice in a dose-dependent manner among 1, 7, and 14mg pyridoxine HCl/kg diet (J Nutr 131: 2204-2207, 2001). To examine the mechanism of the anticolon tumor effect of vitamin B6, male ICR mice were fed the diet containing 1, 7, 14, and 35 mg pyridoxine HCl/kg diet for 22 wk and simultaneously given a weekly injection of azoxymethane for an initial 10 wk. The supplementation of vitamin B6 to a low vitamin B6 diet (1 mg pyridoxine HCl/kg) suppressed the levels of colonic 8-hydroxyguanosine and 4-hydroxynonenal and in-ducible nitric oxide synthase protein. The results suggest that the preventive effect of vita-min B6 against colon tumorigenesis is at least in part mediated by reducing oxidative stress and nitric oxide production.

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