Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Changes in Tissue Protein Synthesis Are Involved in Regulating Urea Synthesis in Rats Given Proteins of Different Quality
Kazuyo TUJIOKASunok LYOUAtushi SANOKazutoshi HAYASEHidehiko YOKOGOSHI
Author information
JOURNALS FREE ACCESS

2004 Volume 50 Issue 5 Pages 356-361

Details
Abstract

The purpose of present study was to determine whether the regulation of urea synthesis is mediated through changes in supply of amino acids by protein synthesis and whether the concentration of ammonia, or activities of amino acid catabolizing enzymes, regulate urea synthesis when the dietary protein quality is manipulated. Experiments were done on three groups of rats given diets containing 10g gluten, 10g casein or 10g whole egg protein/100g for 10d. The urinary excretion of urea, and the liver concentrations of glutamate, serine and alanine increased with a decrease in quality of dietary protein. The fractional and absolute rates of protein synthesis in tissues declined with the decrease in quality of dietary protein quality. The ammonia concentration in plasma and liver, and activities of hepatic amino acid catabolizing enzymes was not related to urea excretion under these conditions. These results suggest that the lower protein synthesis seen in tissues of rats given the lower quality of protein is likely to be one of the factors to increasing the supply of amino acids and stimulating urea synthesis.

Information related to the author
© the Center for Academic Publications Japan
Previous article Next article
feedback
Top