Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in Achilles Tendon
Jun MINAGUCHIYoh-ichi KOYAMANatsuko MEGURIYoshinao HOSAKAHiromi UEDAMasashi KUSUBATAArisa HIROTAShinkichi IRIENaoki MAFUNEKazushige TAKEHANA
著者情報
ジャーナル フリー

2005 年 51 巻 3 号 p. 169-174

詳細
抄録

In order to investigate whether the oral ingestion of collagen peptide affects the extracellular matrix of tendon, two doses (0.2g/kg and 1.0g/kg body weight) were orally administered daily for 56d to a rabbit, and both the size of collagen fibrils and the amount of glycosaminoglycans in the Achilles tendon were measured in comparison with those in a rabbit fed with a control protein, lactalbumin, or water alone. Ingestion of col-lagen peptide or lactalbumin induced a significant increase in collagen fibril diameter and a decrease in fibril density except for a high dose of lactalbumin compared with the water con-trol. A histogram pattern of fibril diameter in a high dose of collagen peptide showed a peak at 160-180nm, which was not observed in other groups. However the percentage of diam-eters over 200nm was the lowest in this group but highest in the low-dose group of collagen peptide. The mean fibril diameter and mass average diameter of a high dose of collagen pep-tide were significantly smaller than those in a low dose. The amount of dermatan sulphate increased in the high-dose groups, while the amount of hyaluronic acid decreased in rabbits fed with collagen peptide or lactalbumin at either dose. These results suggest that the inges-tion of collagen peptide affects the size of collagen fibrils and composition of glycosaminogly-cans in the Achilles tendon and thus may improve the mechanical properties of the Achilles tendon.

著者関連情報
© the Center for Academic Publications Japan
前の記事 次の記事
feedback
Top