Journal of Osaka Dental University
Online ISSN : 2189-6488
Print ISSN : 0475-2058
ISSN-L : 0475-2058
Application of in vitro Bromodeoxyuridine Labeling of Oral Cancers
Masahiro WATOTetsunari NISHIKAWAAtsushi FUJITAYutaka NAGAOKengo TSUJIMOTOKayo MATSUOKAKatsuko HORIIHakuro OKANOAkio TANAKA
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1993 Volume 27 Issue 2 Pages 113-120

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Abstract

We used immunohistochemical methods to investigate whether in vitro labeling with bromodeoxyuridine (BrdU) of oral cancer tissues is useful in pathological diagnosis. BrdU-positive cells were found around the basal region of the epithelium in normal oral mucosa, in a papilloma specimen and in tissue with moderate dysplasia. The labeling rates (percentage of BrdU-positive cells, LR) for these cases were 1.2%, 6.9% and 7.5%, respectively. In well-differentiated carcinoma, more layers of BrdU positive cells were observed from the basal layer toward the surface. The LR in this region was 13.9-17.0%. In vitro BrdU labeling of oral tumors may be useful in pathological diagnosis, since the LR is lowest in normal tissues, higher in benign tumors, and highest in malignant tumor tissues.

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© 1993 Osaka Odontological Society
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