Journal of Occupational Health
Online ISSN : 1348-9585
Print ISSN : 1341-9145
Original
Effects of Concentrated Ambient Particles on Heart Rate Variability in Spontaneously Hypertensive Rats
Chuen-Chau ChangJing-Shiang HwangChang-Chuan ChanPeng-Yau WangTsuey-Hwa HuTsun-Jen Cheng
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Volume 47 (2005) Issue 6 Pages 471-480

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Abstract

In the present study, the cardiovascular toxicity of PM2.5 was determined in spontaneously hypertensive (SH) rats using the standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive differences of adjacent normal-to-normal intervals (RMSSD) as outcome measurements. Four SH rats implanted with radiotelemetry transmitters were repeatedly exposed to concentrated PM2.5 in nose-only exposure chambers. Gravimetric analysis revealed the mean post-concentrating mass concentration of particles during the 5 h of exposure was 202 μg/m3. Using each animal as its own control and linear mixed-effects model, to adjust for circadian nature and individual differences, we found that SDNN decreased by 15% initially then gradually decreased to 60% of the initial value at the end of exposure. Our results indicate that concentrated PM2.5 may decrease SDNN on SH rats during PM exposure. The study also showed that SDNN is more sensitive to PM induced effects than RMSSD.

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© 2005 by the Japan Society for Occupational Health
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