Journal of Occupational Health
Online ISSN : 1348-9585
Print ISSN : 1341-9145
ISSN-L : 1341-9145
Brief Report
Determination Method for Xylidines in Workplace Air
Akito TakeuchiShinobu YamamotoWarren HendricksYasuki NishimuraTsutoshi ImanakaYuichiro KaifukuNorihiro SakuiShuichiro NatsumedaHirokazu OtaShu YamadaIchiro KurotaniKimiaki SuminoSeiichiro Kanno
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2011 Volume 53 Issue 3 Pages 230-233

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Abstract

Objectives: The purpose of this research was to develop a determination method for xylidines (XLDs) in workplace air for risk assessment. Methods: The characteristics of the proposed method, such as recovery, detection limit, reproducibility, and storage stability of the samples were examined. Results: An air sampler cassette containing two sulfuric acid-treated glass fiber filters was chosen as the sampler. The XLDs were extracted from the sampler filters, derivatized with heptafluorobutyric anhydride, and then analyzed by a gas chromatograph equipped with a mass spectrometer. The average recoveries of XLDs from the spiked sampler were 83-101% for personal exposure monitoring. The recovery after 5 days of storage in a refrigerator exceeded 90%. The overall limit of quantitation (LOQ) was 0.600 g/sample. The relative standard deviation, which represents the overall reproducibility defined as precision, was 0.8-10.3%. Conclusions: The proposed method enables 4-hour personal exposure monitoring of XLDs at concentrations equaling 0.001-2 times the threshold limit value-time-weighted average (TLV-TWA: 0.5 ppm) adopted by the American Conference of Governmental Industrial Hygienists, and is useful for estimating worker exposure to XLDs.

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2011 by the Japan Society for Occupational Health
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