Journal of Occupational Health
Online ISSN : 1348-9585
Print ISSN : 1341-9145
ISSN-L : 1341-9145
Originals
Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers
Christian Silva SimonetiAmanda Souza FreitasMichelle Christiane Rodrigues BarbosaErica FerrazMarcelo Bezerra de MenezesEricson BagatinLuisa Karla ArrudaElcio Oliveira Vianna
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML

2016 Volume 58 Issue 1 Pages 7-15

Details
Abstract

Objectives: The aim of this estudy was to investigate the influence of allergen exposure levels and other risk factors for allergic sensitization, asthma, and bronchial hyperresponsiveness (BHR) in workers exposed to laboratory animals. Methods: This was a cross-sectional study performed at two universities, 123 workplaces with 737 subjects. Dust samples were collected from laboratories and animal facilities housing rats, mice, guinea pigs, rabbits, or hamsters and analyzed by enzyme-linked immunosorbent assay (ELISA) to measure allergen concentrations. We also sampled workplaces without animals. Asthma was defined by both symptoms and BHR to mannitol. The concentrations of allergens were tested for association with a skin prick test, respiratory symptoms, spirometry data, and BHR. This multivariate analysis was performed by using Poisson regression to estimate the relative risk (RR) for the exposed group. Results: Our sample comprised students and workers, with 336 subjects in the nonexposed group and 401 subjects in the exposed group. Sixty-nine subjects (17%) had positive results in the skin prick test for animal allergens in the exposed group; in the nonexposed group, 10 subjects had positive results (3%) (p<0.001). Exposure to laboratory animals over 2.8 years was associated with atopic sensitization (RR=1.85; 95% confidence interval: 1.09–3.15; p=0.02). Allergen concentration was not associated with sensitization, asthma, or BHR. Conclusion: Exposure to laboratory animals was associated with atopic sensitization. However, we did not find a cutoff allergen concentration that increased the risk for sensitization. Duration of exposure seems to be more relevant to sensitization than concentration of allergens in dust.(J Occup Health 2016; 58: 7–15)

Information related to the author

This article cannot obtain the latest cited-by information.

2016 by the Japan Society for Occupational Health
Previous article Next article
feedback
Top