産業医学
Online ISSN : 1881-1302
Print ISSN : 0047-1879
HL-60細胞protein kinase C活性に及ぼすアスベストの作用
ラジカルの役割
植木 絢子津島 弘文兵藤 文則絹川 敬吾
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33 巻 (1991) 6 号 p. 485-490

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It was confirmed that the function of DMSO as an inducer of cell differentiation was suppressed by co-culture of crocidolite asbestos, using the activity of protein kinase C as indicator, because DMSO reacted with ·OH radical released by stimulation with crocidolite and wasted itself. SOD inhibited the effect of crocidolite, because SOD reacted with ·O2- released by stimulation with crocidolite and inhibited the subsequent development of ·OH.

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