Sangyo Igaku
Online ISSN : 1881-1302
Print ISSN : 0047-1879
ISSN-L : 0047-1879
ANALYSIS OF ACUTE TOXICITY (LD50-VALUE) OF ORGANIC CHEMICALS TO MAMMALS BY SOLUBILITY PARAMETER (δ)
(3) Acute Dermal Toxicity to Rabbits
Hiroshi NISHIMURAShoji SAITOFumio KISHIDAMasatoshi MATSUO
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JOURNAL FREE ACCESS

1994 Volume 36 Issue 6 Pages 428-434

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Abstract

Acute dermal toxicity (LD50-value) of organic chemicals to rabbits was analyzed by using solubility parameter (δc), a thermodynamic parameter, of the chemicals. As it was observed in the previous studies with rats and mice, parabolic correlations were also established between logarithm of LD50-value (mmol/kg body weight, rabbits) and δc of all the collected chemicals (n=56, R=0.498), alcohols (n=19, R=0.857), ketones (n=7, R=0.711), aldehydes (n=7, R=0.633) and aromatics (n=20, R=0.613). Introduction of molar volume (Vc) to the above equations did not improve the correlations. In the study, we assumed that chemicals absorbed dermally by the mammals similarly disturb the homeostasis, as in acute oral toxicities of organic chemicals to rats and mice. We successfully confirmed the theoretical equation regardless of species and routes of administration by establishing statistically significant correlations with all the collected chemicals, alcohols and aromatics. By analysis, we could determine the solubility parameter of 2.24×104 (J/m3)1/2 for the biological membrane (absorption site) of rabbits. As the dermal δc-values which dip the LD50-values for rabbits are approximately the same as in acute oral toxicities with rats and mice, common deleterious effects and mechanism may be working at the common target sites. The regression curves of LD50-values of rabbits, however, are slightly higher than those of rats and mice, which may reflect the difference in amounts of the chemicals absorbed by the body. For comparison, log P was used to describe LD50 of all the collected chemicals, and significant correlations were observed in parabolic and bilinear equation (n=56, R=0.522, 0.584), but no relationships were established for aromatics.

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