N-Acetylcysteine Fails to Protect Rats from Acrylamide Neurotoxicity

Bambang WISPRIYONO; Yoshihisa IRYO; Tohko YOSHIDA; Masato MATSUOKA; Hideki IGISU

doi:10.1539/joh.41.181

Bambang WISPRIYONO, Yoshihisa IRYO, Tohko YOSHIDA, Masato MATSUOKA, Hideki IGISU

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Keywords: Acrylamide, N-Acetylcysteine, Neurotoxicity, Ataxia, Landing foot spread, Glutathione, Rat

JOURNAL FREE ACCESS

1999 Volume 41 Issue 3 Pages 181-182

DOI https://doi.org/10.1539/joh.41.181

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Published: 1999 Received: December 21, 1998 Available on J-STAGE: April 07, 2006 Accepted: April 23, 1999 Advance online publication: - Revised: -
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Date of correction: April 07, 2006 Reason for correction: - Correction: CITATION Details: Wrong : 1) Igisu H, Goto I, Kawamura Y, Kato M, Izumi K, Kuroiwa Y. Acrylamide encephaloneuropathy due to well water pollution. J Neurol Neurosurg Psychiatry 1975; 38: 581-584.
2) Hashimoto K, Aldridge WN. Biochemical studies on acrylamide, a neurotoxic agent. Biochem Pharmacol 1970; 19:2591-2604.
3) Flanagan RJ, Meredith TJ. Use of N-acetylcysteine in clinical toxicology. Am J Med 1991; 91: 131s-139s.
4) Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989; 6: 593-597.
5) Cotgreave IA. N-Acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol 1997; 38: 205-227.
6) Ferrari G, Yan CYI, Greene LA. N-Acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci 1995; 15: 2857-2866.
7) Knuckey NW, Palm D, Primiano M, Epstein MH, Johanson CE. N-Acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats. Stroke 1995; 26: 305-311.
8) Henderson JT, Javaheri M, Kopko S, Roder JC. Reduction of lower motor neuron degeneration in wobbler mice by N-acetyl-L-cysteine. J Neurosci 1996; 16: 7574-7582.
9) Edwards PM, Parker VH. A simple, sensitive, and objective method for early assessment of acrylamide neuropathy in rats. Toxicol Appl Pharmacol 1977; 40: 589-591.
10) Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman''s reagent. Anal Biochem, 1968; 25: 192-205.
11) Benz FW, Nerland DE, Pierce WM, Babiuk C. Acute acrylonitrile toxicity: studies on the mechanism of the antidotal effect of D- and L-cysteine and their N-acetyl derivatives in the rat. Toxicol Appl Pharmacol 1990; 102: 142-150.
12) Matsuoka M, Matsumura H, Igisu H. Creatine kinase activities in brain and blood: possible neurotoxic indicator of acrylamide intoxication. Occup Environ Med 1996; 53: 468-471.
13) van Klaveren RJ, Dinsdale D, Pype JL, Demedts M, Nemery B. N-Acetylcysteine does not protect against type II cell injury after prolonged exposure to hyperoxia in rats. Am J Physiol 1997; 273: L548-L555.
14) Wispriyono B, Matsuoka M, Igisu H, Matsuno K. Protection from cadmium cytotoxicity by N-acetylcysteine in LLC-PK₁ cells. J Pharmacol Exp Ther 1998; 287: 344-351.

Right : 1) Igisu H, Goto I, Kawamura Y, Kato M, Izumi K, Kuroiwa Y. Acrylamide encephaloneuropathy due to well water pollution. J Neurol Neurosurg Psychiatry 1975; 38: 581-584.
2) Hashimoto K, Aldridge WN. Biochemical studies on acrylamide, a neurotoxic agent. Biochem Pharmacol 1970; 19:2591-2604.
3) Flanagan RJ, Meredith TJ. Use of N-acetylcysteine in clinical toxicology. Am J Med 1991; 91: 131s-139s.
4) Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989; 6: 593-597.
5) Cotgreave IA. N-Acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol 1997; 38: 205-227.
6) Ferrari G, Yan CYI, Greene LA. N-Acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci 1995; 15: 2857-2866.
7) Knuckey NW, Palm D, Primiano M, Epstein MH, Johanson CE. N-Acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats. Stroke 1995; 26: 305-311.
8) Henderson JT, Javaheri M, Kopko S, Roder JC. Reduction of lower motor neuron degeneration in wobbler mice by N-acetyl-L-cysteine. J Neurosci 1996; 16: 7574-7582.
9) Edwards PM, Parker VH. A simple, sensitive, and objective method for early assessment of acrylamide neuropathy in rats. Toxicol Appl Pharmacol 1977; 40: 589-591.
10) Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem, 1968; 25: 192-205.
11) Benz FW, Nerland DE, Pierce WM, Babiuk C. Acute acrylonitrile toxicity: studies on the mechanism of the antidotal effect of D- and L-cysteine and their N-acetyl derivatives in the rat. Toxicol Appl Pharmacol 1990; 102: 142-150.
12) Matsuoka M, Matsumura H, Igisu H. Creatine kinase activities in brain and blood: possible neurotoxic indicator of acrylamide intoxication. Occup Environ Med 1996; 53: 468-471.
13) van Klaveren RJ, Dinsdale D, Pype JL, Demedts M, Nemery B. N-Acetylcysteine does not protect against type II cell injury after prolonged exposure to hyperoxia in rats. Am J Physiol 1997; 273: L548-L555.
14) Wispriyono B, Matsuoka M, Igisu H, Matsuno K. Protection from cadmium cytotoxicity by N-acetylcysteine in LLC-PK₁ cells. J Pharmacol Exp Ther 1998; 287: 344-351.

Date of correction: April 07, 2006 Reason for correction: - Correction: PDF FILE Details: -

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