Conditioned Media from Human Dental Pulp Stem Cells Prevent Radiation-induced Skin Injury

Keita KAWARABAYASHI; Fumiya KANO; Noboru HASHIMOTO; Hideharu HIBI; Tsutomu IWAMOTO; Akihito YAMAMOTO

doi:10.20738/johb.33.1_1

原著論文

Conditioned Media from Human Dental Pulp Stem Cells Prevent Radiation-induced Skin Injury

Keita KAWARABAYASHI , Fumiya KANO, Noboru HASHIMOTO, Hideharu HIBI, Tsutomu IWAMOTO, Akihito YAMAMOTO

著者情報

Keita KAWARABAYASHI [日本] 責任著者
Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School [日本]
Pediatric Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School [日本]
Fumiya KANO [日本]
Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School [日本]
Noboru HASHIMOTO [日本]
Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School [日本]
Hideharu HIBI [日本]
Department of Oral and Maxillofacial Surgery Nagoya University Graduate School of Medicine [日本]
Tsutomu IWAMOTO [日本]
Pediatric Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School [日本]
Akihito YAMAMOTO [日本]
Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School [日本]

キーワード: Human dental pulp stem cells, conditioned media, mesenchymal stem cells, Radiation-induced skin reactions, Cutaneous radiation syndrome

ジャーナルオープンアクセス

2020 年 33 巻 1 号 p. 1-7

DOI https://doi.org/10.20738/johb.33.1_1

詳細

抄録

Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. In this study, we investigated the impact of SHED-conditioned medium (SHED-CM) on radiation-induced skin injury. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema. Intra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration.

責任著者(Corresponding author)

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